Integrin beta 1/CD29 Antibody (JB1B) Summary
| Immunogen |
Purified Human beta1 integrin
|
| Marker |
Stem Cell Marker
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| Specificity |
NB100-64804 reacts with Human Integrin beta1 as confirmed with beta1 transfectants and by reciprocal preclearing of beta1 reactivity with anti-beta1. The antibody stimulates the adherence of several cell types. The removal of azide is recommended prior to use in functional assays.
|
| Isotype |
IgG2a
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
ITGB1
|
| Purity |
Protein A or G purified
|
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Reactivity Notes
Reacts with Human. Cross reacts with Cynomolgus monkey and Rhesus Monkey. Does not react with Rat. Reacts weakly with Pig.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Phosphate buffered saline
|
| Preservative |
0.09% Sodium Azide
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| Concentration |
0.5 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for Integrin beta 1/CD29 Antibody (JB1B)
- CD29 antigen
- CD29
- Fibronectin receptor subunit beta
- FNRBVLAB
- GPIIA
- Integrin beta 1
- integrin beta-1
- integrin VLA-4 beta subunit
- integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includesMDF2, MSK12)
- ITGB1
- MDF2
- MSK12
- very late activation protein, beta polypeptide
- VLA-4 subunit beta
- VLA-BETA
Background
Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known as CD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.