Integrin alpha E/CD103 Antibody (Ber-ACT8) Summary
| Immunogen |
HTLV-1 induced human T cell line MAPS16
|
| Specificity |
The mouse monoclonal antibody Ber-ACT8 recognizes CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes. HLDA V; WS Code A067
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
ITGAE
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
15mM Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for Integrin alpha E/CD103 Antibody (Ber-ACT8)
- antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide
- CD103 antigen
- CD103
- HML-1 antigen
- HUMINAE
- Integrin alpha E
- integrin alpha-E
- Integrin alpha-IEL
- integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alphapolypeptide)
- ITGAE
- MGC141996
- Mucosal lymphocyte 1 antigen
Background
CD103 / Integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation