Integrin alpha E/CD103 Antibody (B-Ly7) Summary
| Immunogen |
The immunogen for this antibody was CD103/Integrin alpha E.
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
ITGAE
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| Purity |
Protein A or G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The B-Ly7 antibody has been tested by flow cytometric analysis of 2-3 day PHA-activated human peripheral blood leukocytes. This can be used at less than or equal to 0.5 ug per test. Cell number should be determined empirically but can range from 10^5to 10^8cells/test.
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Aqueous, may contain carrier protein/stabilizer.
|
| Preservative |
0.09% Sodium Azide
|
| Purity |
Protein A or G purified
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Alternate Names for Integrin alpha E/CD103 Antibody (B-Ly7)
- antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide
- CD103 antigen
- CD103
- HML-1 antigen
- HUMINAE
- Integrin alpha E
- integrin alpha-E
- Integrin alpha-IEL
- integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alphapolypeptide)
- ITGAE
- MGC141996
- Mucosal lymphocyte 1 antigen
Background
The B-Ly7 monoclonal antibody reacts with human CD103/Integrin alpha E, the alphaE integrin. CD103/Integrin alpha E non-covalently associates with integrin beta7. CD103/Integrin alpha E is expressed mainly on intraepithelial lymphocytes and a small subset of peripheral lymphocytes. CD103/Integrin alpha E is also expressed by hairy cell leukemia (HCL) and by some chronic B cell lymphocytic leukemias. In vitro stimulation of human T cells with mitogens induces upregulation of CD103/Integrin alpha E. Epithelial cell antigen, E-cadherin, binds to CD103/Integrin alpha E and mediates homing of lymphocytes to the intestinal epithelium.