Integrin alpha E/CD103 Antibody (AP-MAB0828) Summary
| Immunogen |
Mouse mammary tumor cells
|
| Specificity |
Integrin alpha IEL chain
|
| Isotype |
IgG2
|
| Clonality |
Monoclonal
|
| Host |
Rat
|
| Gene |
ITGAE
|
| Purity |
Protein A or G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Flow Cytometry, Immunoprecipitation, Immunohistochemistry-Frozen and Inhibition of CD103 mediated adhesion
|
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
A 0.2 um filtered solution in PBS – Azide free
|
| Preservative |
No Preservative
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for Integrin alpha E/CD103 Antibody (AP-MAB0828)
- antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide
- CD103 antigen
- CD103
- HML-1 antigen
- HUMINAE
- Integrin alpha E
- integrin alpha-E
- Integrin alpha-IEL
- integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alphapolypeptide)
- ITGAE
- MGC141996
- Mucosal lymphocyte 1 antigen
Background
CD103 has a unique and fairly restricted tissue distribution. It is expressed on almost all intestinal intraepithelial lymphocytes (IEL), on dendritic epidermal T cells (DEC), on subpopulations of peripheral T cells, and on distinct subsets of fetal, neonatal, and adult thymocytes. E-cadherin is the epithelial-cell ligand for CD103. The ordered expression of alpha IEL during thymocyte development (which occurs under the influence of the thymic epithelium), the high level of expression of alphaIEL on those peripheral T cells found in epithelial tissues (IEL and DEC), and the expression of CD103 on a subset of CD8+ lymphocytes responding to allogeneic epithelial cells suggest that CD103 may have a common role in the interactions of T lymphocytes with epithelia during T-cell maturation and effector functions. This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse mammary tumor cells.