Integrin alpha 2/CD49b Antibody (235033) [Allophycocyanin] Summary
| Immunogen |
Mouse myeloma cell line NS0-derived recombinant mouse Integrin alpha 2/CD49b
Tyr27-Thr1129 Accession # Q62469 |
| Specificity |
Detects mouse Integrin alpha 2/CD49b in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse Integrin alpha 3, alpha 4, alpha 5, alpha E, or alpha V is observed.
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| Source |
N/A
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| Isotype |
IgG2b
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| Clonality |
Monoclonal
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| Host |
Rat
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| Gene |
ITGA2
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Applications/Dilutions
| Dilutions |
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| Publications |
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Packaging, Storage & Formulations
| Storage |
Protect from light. Do not freeze.
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| Buffer |
Supplied in a saline solution containing BSA and Sodium Azide.
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| Preservative |
Sodium Azide
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Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Integrin alpha 2/CD49b Antibody (235033) [Allophycocyanin]
- alpha-2 subunit
- CD49b antigen
- CD49b
- Integrin alpha 2
- integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
- ITGA2
- VLA 2
- VLA-2 alpha
Background
The Integrin alpha 2 subunit, also known as CD49b and VLA-2 alpha subunit, forms a heterodimer with beta 1 Integrin. The alpha 2 beta 1 Integrin is a collagen receptor that binds expressing cells to collagen and regulates collagen and collagenase secretion. Notably, this subunit has an “I” domain that is resistant to proteolysis. Over amino acids
(aa) 27-1129, mouse Integrin alpha 2 shares 80% aa sequence identity with human Integrin alpha 2.
(aa) 27-1129, mouse Integrin alpha 2 shares 80% aa sequence identity with human Integrin alpha 2.