Inhibin alpha Antibody (4E2) Summary
| Immunogen |
Purified recombinant fragment of human INHA expressed in E. Coli.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
|
| Gene |
INHA
|
| Purity |
Unpurified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human, Mouse. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
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Alternate Names for Inhibin alpha Antibody (4E2)
- A-inhibin subunit
- INHA
- Inhibin A
- inhibin alpha chain
- inhibin, alpha
Background
INHA(A-inhibin subunit precursor, inhibin alpha subunit ),also called inhibin(alpha),which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.