IL-4 Antibody (MP4-25D2) Summary
| Immunogen |
Purified CHO cell expressed recombinant human IL-4.
|
| Specificity |
Specific for human Interleukin 4 (IL-4), a 20kD cytokine which is expressed by a subpopulation of activated T cells and mast cells. Clone MP4-25D2 is reported to neutralise IL-4 activity (2,5).
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Rat
|
| Gene |
IL4
|
| Purity |
Protein A or G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
||
| Positive Control |
|
Reactivity Notes
Cross reacts with Rhesus Monkey.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A or G purified
|
Alternate Names for IL-4 Antibody (MP4-25D2)
- B cell growth factor 1
- BCDF
- B-cell stimulatory factor 1
- BCGF1
- BCGF-1
- binetrakin
- BSF1
- BSF-1
- IL4
- IL-4
- IL-4B_cell stimulatory factor 1
- interleukin 4
- interleukin-4
- Lymphocyte stimulatory factor 1
- MGC79402
- pitrakinra
Background
IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of native CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. This clone is reported to neutralise IL4 activity.