IKK epsilon/IKBKE Antibody Summary
| Immunogen |
Antibody was raised against a 16 amino acid peptide near the carboxy terminus of human IKK epsilon. The immunogen is located within the last 50 amino acids of IKK epsilon.
|
| Specificity |
It has no cross response to IKKa, IKKb, or IKKy.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
IKBKE
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
||
| Application Notes |
IKK epsilon antibody can be used for detection of IKK epsilon by Western blot at 0.5 to 1 mg/ml. An 80 kDa band should be detected. It has no cross response to IKKa, IKKb, or IKKy. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
||
| Theoretical MW |
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
||
| Control Peptide |
|
||
| Publications |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for IKK epsilon/IKBKE Antibody
- EC 2.7.11
- EC 2.7.11.10
- I-kappa-B kinase epsilon
- IKBKE
- IKK epsilon
- IKK-E
- IKKEMGC125297
- IKK-epsilon
- IKKI
- IKK-I
- IKK-iMGC125295
- Inducible I kappa-B kinase
- inducible IkappaB kinase
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
- inhibitor of nuclear factor kappa-B kinase subunit epsilon
- KIAA0151IKK-related kinase epsilon
- MGC125294
Background
Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappaB is associated with IkappaB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. IkappaB is phosphorylated by IkappaB kinase (IKK) complex that contains IKKalpha, IKKbeta, and IKKgamma. A novel molecule in the IKK complex was recently identified and designated IKKepsilon/IKK-i. IKK epsilon is required for the activation of NF-kappaB by PMA and T cell receptors but not by TNFalpha and IL-1. IKKepsilon/IKK-i message is expressed in a variety of tissues and is inducible by TNFalpha, IL-1, and LPS.