IKK beta Antibody (1A3) Summary
| Immunogen |
IKBKB (AAH06231 3 a.a. – 120 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. WSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
|
| Specificity |
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
|
| Isotype |
IgG2a Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
IKBKB
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for ELISA.
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for IKK beta Antibody (1A3)
- EC 2.7.11
- EC 2.7.11.10
- I-kappa-B kinase 2
- I-kappa-B-kinase beta
- IkBKB
- IKK beta
- IKK2
- IKK2FLJ38368
- IKK-B
- IKK-betaFLJ36218
- IKKBFLJ40509
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
- inhibitor of nuclear factor kappa-B kinase subunit beta
- MGC131801
- NFKBIKB
- NFKBIKBFLJ33771
- Nuclear factor NF-kappa-B inhibitor kinase beta
Background
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]