IKK beta Antibody (10A2C5B3) Summary
| Immunogen |
Purified recombinant fragment of IKBKB expressed in E. Coli.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
IKBKB
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for IKK beta Antibody (10A2C5B3)
- EC 2.7.11
- EC 2.7.11.10
- I-kappa-B kinase 2
- I-kappa-B-kinase beta
- IkBKB
- IKK beta
- IKK2
- IKK2FLJ38368
- IKK-B
- IKK-betaFLJ36218
- IKKBFLJ40509
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
- inhibitor of nuclear factor kappa-B kinase subunit beta
- MGC131801
- NFKBIKB
- NFKBIKBFLJ33771
- Nuclear factor NF-kappa-B inhibitor kinase beta
Background
IKK-beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP (1-2). Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta (3). Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response (4). Additionally, IKK-beta activity can also be regulated by MEKK-1 (5).