Huntingtin Antibody (3-19) Summary
| Immunogen |
Synthetic peptide conjugated to KLH via cysteine corresponding to residues C-HTLQADSVD (505-513) of Human HTT.
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| Isotype |
IgG
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
HTT
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Neoepitope antibodies distinguish smaller cleaved fragments or processed forms of proteins versus the intact full-length or precursor by using a designed peptide purification process to maximize immunoreactivity to a specific cleavage site. Human HTT caspase cleavage sites generate fragment-specific forms of the protein. Caspase-3/7 has been shown to generate cleavage sites at animo acids 513 and 552. Caspase-2 cleaves at amino acid 552 and caspase-6 at amino acid 586.
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Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS with 1 mg/ml BSA.
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| Preservative |
0.05% Sodium Azide
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| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
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Alternate Names for Huntingtin Antibody (3-19)
- HD protein
- huntingtin (Huntington disease)
- huntingtin
- IT15HDHuntington disease protein