Hexokinase 1 Antibody (4D7) Summary
| Immunogen |
Recombinant human Hexokinase1 (1-917aa) purified from E. coli
|
| Specificity |
The antibody recognizes all four isoforms of Hexokinase (1~4) in recombinant protein.
|
| Isotype |
IgG2a Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
HK1
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
This antibody is reactive against Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4) and 10% Glycerol
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for Hexokinase 1 Antibody (4D7)
- Brain form hexokinase
- EC 2.7.1
- EC 2.7.1.1
- glycolytic enzyme
- Hexokinase 1
- Hexokinase type I
- hexokinase-1
- HK I
- HK1
- HK1-ta
- HK1-tb
- HK1-tc
- HKI
- HXK1
Background
Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP. In mammals, four distinct enzymes-types 1 to 4 hexokinases-have been identified. The enzyme is found in most cells, but there is tissue specificity for theparticular type of hexokinase. Hexokinase1 is found in the adipose tissue and liver and encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this hexokinase1 have been associated with hemolytic anemia due to hexokinase deficiency.