HLA DMB Antibody (5G11) Summary
| Immunogen |
HLA-DMB (NP_002109, 22 a.a. – 129 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. VAHVESTCLLDDAGTPKDFTYCISFNKDLLTCWDPEENKMAPCEFGVLNSLANVLSQHLNQKDTLMQRLRNGLQNCATHTQPFWGSLTNRTRPPSVQVAKTTPFNTRE
|
| Specificity |
HLA-DMB – major histocompatibility complex, class II, DM beta (5G11)
|
| Isotype |
IgG2b Kappa
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
HLA-DMB
|
| Purity |
Ascites
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
Ascites
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for HLA DMB Antibody (5G11)
- class II histocompatibility antigen, M beta chain
- D6S221E
- DMB
- major histocompatibility complex, class II, DM beta
- MHC class II antigen DMB
- MHC class II antigen HLA-DM beta chain
- MHC class II HLA-DMB
- Really interesting new gene 7 protein
- RING7HLA class II histocompatibility antigen, DM beta chain
Background
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq]