GnRHR Antibody (A9E4) Summary
| Immunogen |
A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor.
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| Localization |
Cytoplasmic
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| Specificity |
Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations
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| Isotype |
IgG1 Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Purity |
Protein A or G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Hu-chromosome location: 4q21.2 (GNRHR) and 2p16.3 (LHCGR) (Human)
Molecular weight of antigen: 54-60kDa. . In Simple Western only 10 – 15 uL of the recommended dilution is used per data point. Separated by Size. |
Reactivity Notes
Human, Predicted to react with Pig, Rabbit. Others-not known.
Packaging, Storage & Formulations
| Storage |
Store at 4C.
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| Buffer |
10mM PBS and 0.05% BSA
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| Preservative |
0.05% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Protein A or G purified
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Alternate Names for GnRHR Antibody (A9E4)
- GnRH receptor
- GnRHR
- GnRH-R
- GNRHR1
- gonadotropin-releasing hormone (type 1) receptor 1
- gonadotropin-releasing hormone receptor
- GRHR
- HH7
- leutinizing-releasing hormone receptor
- LHRHR
- LHRHRleutinizing hormone releasing horomone receptor
- LRHR
- luliberin receptor
- Luliberin
- type I GnRH receptor