GSK-3 alpha Antibody (6G2F1) Summary
| Immunogen |
Purified recombinant fragment of GSK3 alpha expressed in E. Coli.
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
GSK3A
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for GSK-3 alpha Antibody (6G2F1)
- DKFZp686D0638
- EC 2.7.11
- EC 2.7.11.26
- glycogen synthase kinase 3 alpha
- glycogen synthase kinase-3 alpha
- GSK3 alpha
- GSK-3 alpha
- GSK3A
Background
Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.