GR/NR3C1 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the C-terminus region of human Glucocorticoid receptor. The exact sequence is proprietary.
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| Localization |
Cytoplasm; Nucleus
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
|
| Gene |
NR3C1
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
86 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Chicken (88%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1.02 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for GR/NR3C1 Antibody
- GCR
- glucocorticoid receptor
- GR
- GRGCCR
- GRLNuclear receptor subfamily 3 group C member 1
- NR3C1
- nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- nuclear receptor subfamily 3, group C, member 1
Background
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq]