Product: D-Mannitol 1,2:5,8-bis-acetonide
GADD153/CHOP Antibody Summary
| Immunogen |
Full length human GADD153 Recombinant protein.
|
| Localization |
Nucleus
|
| Marker |
ER Stress Marker
|
| Predicted Species |
Rat (90%), Porcine (95%), Bovine (92%), Monkey (98%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
DDIT3
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
IHC-R. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
19 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Rhesus Monkey (98%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for GADD153/CHOP Antibody
- C/EBP-homologous protein 10
- C/EBP-homologous protein
- CCAAT/enhancer-binding protein homologous protein
- CEBP zeta
- CHOP
- CHOP10 CEBPZ
- CHOP10
- CHOP-10
- CHOPC/EBP zeta
- DDIT3
- DDIT-3
- DNA damage-inducible transcript 3 protein
- DNA-damage-inducible transcript 3
- GADD153
- Growth arrest and DNA damage-inducible protein GADD153
Background
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq]