Frizzled-3 Antibody

Product: NSC319727

Frizzled-3 Antibody Summary

Immunogen
Synthetic peptide located within the last 100 amino acids of NP_059108.1
Specificity
Human FZD3
Clonality
Polyclonal
Host
Rabbit
Gene
FZD3
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 20 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Frizzled-3 Antibody

  • frizzled (Drosophila) homolog 3
  • frizzled homolog 3 (Drosophila)
  • Frizzled3
  • Frizzled-3
  • Fz-3
  • FZD3
  • hFz3

Background

Frizzled-3 (FZD3) is a Frizzled Receptor that mediates Wnt signaling. It is widely expressed, mostly in brain and urogenital tissues. FZD3 is also expressed in the epidermis and developing hair follicles. FZD3 has been implicated in the development of axon tracts in the forebrain. A truncated form of FZD3 exists due to alternative splicing. FZD3 expression has been documented in blood, brain, colon, kidney, lung, lymph node, ovary, pancreas, skeletal muscle, skin, spinal cord, stomach, urogenital tract, and uterus. ESTs have been isolated from amnion, brain, colon, eye, heart, kidney, lymph, skin, and testis libraries.

PMID: 15961563

Frizzled-3 Antibody

Product: Diazoxide

Frizzled-3 Antibody Summary

Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Frizzled 3. The exact sequence is proprietary.
Localization
Membrane, Multi-pass membrane protein
Specificity
Antibody reactive against peptide, detects immunogen. Further validation in progress.
Predicted Species
Rat (100%), Bovine (100%), Xenopus (100%), Rhesus Macaque (100%), Chicken (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
FZD3
Purity
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry 1:10 – 1:500
Application Notes
Antibody reactive against peptide, detects immunogen. Further validation in progress. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
76 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
Preservative
0.01% Thimerosal
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Frizzled-3 Antibody

  • frizzled (Drosophila) homolog 3
  • frizzled homolog 3 (Drosophila)
  • Frizzled3
  • Frizzled-3
  • Fz-3
  • FZD3
  • hFz3

Background

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development.

PMID: 24745017