Product: NH3-KLGADTDGEQDQHMTYGGQ-COOH
Fibulin 5/DANCE Antibody (1G6A4) Summary
| Immunogen |
Purified recombinant fragment of FBLN5(aa242-448) expressed in E. Coli.
|
| Specificity |
Specific for FBLN5.
|
| Isotype |
IgG1
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| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
FBLN5
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for Fibulin 5/DANCE Antibody (1G6A4)
- ARMD3fibulin-5
- DANCE
- DANCEFIBL-5
- Developmental arteries and neural crest EGF-like protein
- EVEC
- FBLN5
- Fibulin 5
- UP50
- UP50FLJ90059
- Urine p50 protein
Background
The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.