FYB/ADAP/SLAP130 Antibody Summary
| Immunogen |
Antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human ADAP. The immunogen is located within amino acids 60 – 110 of ADAP.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
FYB
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for FYB/ADAP/SLAP130 Antibody
- ADAP
- Adhesion and degranulation promoting adaptor protein
- adhesion and degranulation-promoting adaptor protein
- FYB
- FYB-120/130SLAP-130FYN-binding protein (FYB-120/130)
- FYN binding protein
- FYN-binding protein
- FYN-T-binding protein
- p120/p130
- PRO0823
- SLAP130
- SLP-76-associated phosphoprotein
Background
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion. TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappaB family of transcription factors. More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell-antigen presenting cell (APC) activation. At least three isoforms of ADAP are known to exist.