FIP1L1 Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 544 and 594 of human factor interacting with PAP using the numbering given in entry NP_112179.2 (GeneID 81608).
|
| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
FIP1L1
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for FIP1L1 Antibody
- DKFZp586K0717
- EC 1.1.1.86
- EC 4.2.1.33
- Factor interacting with PAP
- FIP1 like 1 (S. cerevisiae)
- FIP1
- FIP1-like 1 protein
- FLJ33619
- hFip1
- pre-mRNA 3-end-processing factor FIP1
- Rearranged in hypereosinophilia
- Rhe
Background
FIP1 was originally identified as Rhe (rearranged in hypereosinophilia) and part of a fusion protein encoded by a genetic rearrangement between the N-terminal region of FIP1 (Rhe) and the C-terminal region of the platelet-derived growth factor receptor alpha (PDGFRalpha). The fusion protein exhibits aberrant tyrosine kinase activity and is associated with hypereosinophilic syndrome (HES); a rare hematologic disorder characterized by an overproduction of eosinophils that results in organ damage. FIP1 was also identified as FIP1-like 1 in a database search for a human homolog of the yeast Fip1p (factor interacting with PAP), a subunit of the yeast 3-end processing complex, CPF (cleavage and polyadenylation factor). Human FIP1 was similarly found to interact with PAP and CPSF160 as part of the human CPSF (cleavage and polyadenylation specificity factor) complex. In association with CPSF160, FIP1 is able to recognize U-rich elements on pre-mRNA and stimulate PAP activity.