ErbB3/Her3 Antibody (3F10F6) Summary
| Immunogen |
Purified recombinant fragment of ERBB3(aa1175-1275) expressed in E. Coli.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
ERBB3
|
| Purity |
Unpurified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for ErbB3/Her3 Antibody (3F10F6)
- c-erbB3
- EC 2.7.10
- EC 2.7.10.1
- ErbB3
- ErbB-3
- erbB3-S
- HER3
- HER3c-erbB-3
- LCCS2
- lethal congenital contracture syndrome 2
- MDA-BF-1
- MGC88033
- p180-ErbB3
- p45-sErbB3
- p85-sErbB3
- Proto-oncogene-like protein c-ErbB-3
- receptor tyrosine-protein kinase erbB-3
- Tyrosine kinase-type cell surface receptor HER3
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Background
The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.