EpCAM/TROP1 Antibody (PAN-EpCAM (Cocktail)) [DyLight 350] Summary
Immunogen |
Recombinant human Ep-CAM protein (full-length and fragments)
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Localization |
Cell surface
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Marker |
Epithelial Marker
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Specificity |
It is a cocktail of four highly specific monoclonal antibodies (EGP40/826, EGP40/837, EGP40/1110, EGP40/1120) that recognize extracellular as well as intracellular domains of the epithelial cellular adhesion molecule (Ep-CAM). It is a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or Ep-CAM. Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. This epithelial antigen plays an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma otherwise classified as node-negative. Epithelial antigen has also been suggested as a discriminator between basal cell and baso-squamous carcinomas, and squamous cell carcinoma of the skin.
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Isotype |
IgG1 Kappa
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Clonality |
Monoclonal
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Host |
Mouse
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Gene |
TACSTD1, EPCAM
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Purity |
Protein A or G purified
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Applications/Dilutions
Dilutions |
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Application Notes |
Optimal dilution of this antibody shomld be experimentally determined.
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Packaging, Storage & Formulations
Storage |
Store at 4C in the dark.
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Buffer |
50mM Sodium Borate
|
Preservative |
0.05% Sodium Azide
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Purity |
Protein A or G purified
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Notes
Alternate Names for EpCAM/TROP1 Antibody (PAN-EpCAM (Cocktail)) [DyLight 350]
- 17-1A
- 323/A3
- ACSTD1
- antigen identified by monoclonal AUA1
- CD326 antigen
- CD326
- Cell surface glycoprotein Trop-1
- chromosome 4, surface marker (35kD glycoprotein)
- DIAR5
- EGP
- EGP-2
- EGP314
- EGP40
- EpCAM
- epithelial cell adhesion molecule
- Epithelial cell surface antigen
- Epithelial glycoprotein 314
- Epithelial glycoprotein
- ESA
- GA733-2
- GA733-2EGP34
- gp40
- hEGP314
- HNPCC8
- KS 1/4 antigen
- KS1/4
- KSAHEA125
- M1S2
- M4S1
- M4S1Ly74
- Major gastrointestinal tumor-associated protein GA733-2
- MIC18MH99
- MOC31
- TACST-1
- TACSTD1
- TROP1
- TROP1CD326
- Tumor-associated calcium signal transducer 1CO-17A