Endothelial Cells Antibody (OX-43) Summary
| Immunogen |
Rat peritoneal macrophages
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| Specificity |
NB100-65425 recognizes an antigen of 90kD expressed on all vascular endothelial cells in the rat, with the exception of those in the brain. The antibody also recognizes resident and activated peritoneal macrophages, a subset of alveolar macrophages and erythrocytes.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Purity |
Protein G purified
|
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Applications/Dilutions
| Dilutions |
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| Publications |
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Reactivity Notes
Reacts with Rat.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
|
| Purity |
Protein G purified
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Alternate Names for Endothelial Cells Antibody (OX-43)
- Endothelium
Background
The endothelium is located at the interface between the blood and the vessel wall. The cells are in close contact and form a slick layer that prevents blood cell interaction with the vessel wall as blood moves through the vessel lumen. The endothelium consists of simple squamous epithelium that lines the lumen of all blood vessels. It plays a critical role in the mechanics of blood flow, the regulation of coagulation, leukocyte adhesion, and vascular smooth muscle cell growth, and also serves as a barrier to the transvascular diffusion of liquids and solutes. For years the endothelium was thought of as an inert single layer of cells that passively allow the passage of water and other small molecules across the vessel wall. However, this dynamic tissue performs many other active functions, such as the secretion and modification of vasoactive substances and the contraction and relaxation of vascular smooth muscle.