EZH2/KMT6 Antibody Summary
| Immunogen |
Antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human EZH2. The immunogen is located within amino acids 190 – 240 of EZH2.
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| Specificity |
Multiple isoforms of EZH2 are known to exist. EZH2 antibody is predicted to not cross-react with EZH1.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
EZH2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for EZH2/KMT6 Antibody
- EC 2.1.1
- EC 2.1.1.43
- enhancer of zeste (Drosophila) homolog 2
- enhancer of zeste 2
- enhancer of zeste homolog 2 (Drosophila)
- Enhancer of zeste homolog 2
- ENX1
- ENX-1KMT6EZH1KMT6A
- EZH2
- histone-lysine N-methyltransferase EZH2
- KMT6
- Lysine N-methyltransferase 6
- MGC9169
Background
EZH2 was initially identified as a homolog of the drosophila Enhancer of Zeste through exon trap screening of chromosome 21. Both EZH2 and the related protein EZH1 can form complexes with the noncanonical Polycomb repressive complex-2 (PRC2) and maintain repressive chromatin, but the PRC2-EZH1 complex mediates methylation of histone H3. Both EZH1 and EZH2 are thought to function in the maintenance of embryonic stem cell pluripotency and plasticity and recently have been shown to be essential for hair follicle homeostasis and wound repair. Overexpression of EZH2 has been reported as a marker for advanced and metastatic cancers.