Product: PNU-282988 (S enantiomer free base)
ERK2 Antibody (3F8) Summary
| Immunogen |
Purified recombinant fragment of human MAPK1 expressed in E. Coli.
|
| Isotype |
IgG2b
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MAPK1
|
| Purity |
Unpurified
|
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for ERK2 Antibody (3F8)
- EC 2.7.11
- EC 2.7.11.24
- ERK
- ERK2
- ERK-2
- ERK2MAP kinase isoform p42
- ERT1
- Extracellular signal-regulated kinase 2
- MAP kinase 1
- MAP kinase 2
- MAPK 1
- MAPK1
- MAPK2
- mitogen-activated protein kinase 1
- Mitogen-activated protein kinase 2
- p38
- p40
- p41
- p41mapk
- p42mapk
- p42-MAPK
- PRKM1
- PRKM1MAPK 2
- PRKM2
- protein tyrosine kinase ERK2
Background
ERK2 (also designated extracellular-signal-related kinase 2 or mitogen-activated protein kinase 1), with 360-amino acid protein (about 40kDa), belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of ERK2 requires its phosphorylation by upstream kinases. ERK2 is located in the cytoplasm of resting cells and translocates into the nucleus upon extracellular stimuli by active transport of a dimer. ERK2 is essential for placental development and ERK2 in the trophoblast compartment may be indispensable for the vascularization of the labyrinth.