EPC1 Antibody

Product: Corylin

EPC1 Antibody Summary

Immunogen
This antibody was made against a protein fragment from the Middle Region
Epitope
SECSVGNRAVTQMPSGMEKEEEQEKHLQEAIAAQQASTSGIQLNHVIPTPKVDRVEDQRYHSTYHNKNKMHRSKYIKVHAWQALERDEPEYDYDTEDEAW
Clonality
Polyclonal
Host
Rabbit
Gene
EPC1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:10000
  • Chromatin Immunoprecipitation 1:10-1:500
  • ELISA 1:100-1:2000
Application Notes
This antibody is useful in Chromatin Immunoprecipitation, ELISA and Western Blot.
Publications
Read Publications using 29560002.

Reactivity Notes

Caenorhabditis elegans

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
Preservative
No Preservative
Purity
Immunogen affinity purified

Notes

This product was created from the ModEncode Project, a part of the NHGRI, and is sold by SDIX and Novus Biologicals. These C. elegans antibodies were generated in the labs of Jason Lieb, Susan Strome, Julie Ahringer, Arshad Desai, and Abby Dernburg.

Alternate Names for EPC1 Antibody

  • DKFZp781P2312
  • enhancer of polycomb 1
  • enhancer of polycomb homolog 1 (Drosophila)
  • enhancer of polycomb homolog 1
  • Epl1

Background

EPC1 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome – DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.

PMID: 15539556