EMMPRIN/CD147 Antibody (8D6) [Alexa Fluor® 488] Summary
| Immunogen |
Human T cell line Molt 13
|
| Localization |
Cell surface
|
| Specificity |
This MAb recognizes extracellular epitope 2 within the N-terminal Ig domain of human CD147. It is expressed more intensely on thymocytes than on mature peripheral blood T cells. CD147 is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. It stimulates the production of interstitial collagenase, gelatinase A, stromelysin-1 and various metalloproteinases (MMPs) by fibroblasts. These enzymes are important factors in cancer invasion and metastasis.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
BSG
|
| Purity |
Protein G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Inhibits Homotypic Aggregation, Adhesion to Matrix Proteins, and Migation through Matrigel; Immunohistochemistry (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
|
Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
50mM Sodium Borate
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein G purified
|
Alternate Names for EMMPRIN/CD147 Antibody (8D6) [Alexa Fluor® 488]
- 5F7
- basigin (Ok blood group)
- Basigin
- BSG
- CD147 antigen
- CD147
- Collagenase stimulatory factor
- EMMPRIN
- EMMPRINTCSF
- Extracellular matrix metalloproteinase inducer
- Leukocyte activation antigen M6
- M6
- OK blood group antigen
- OK
- Tumor cell-derived collagenase stimulatory factor