EEA1 Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 100 and 150 of human early endosome antigen 1 using the numbering given in entry NP_003557.2 (GeneID 8411).
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| Marker |
Early Endosome Marker
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
EEA1
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
TBS and 0.1% BSA
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
0.2 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for EEA1 Antibody
- early endosome antigen 1
- early endosome antigen 1, 162kD
- early endosome-associated protein
- EEA1
- Endosome-associated protein p162
- MST105
- MSTP105
- ZFYVE2
- ZFYVE2MST105
- Zinc finger FYVE domain-containing protein 2
Background
Early endosomal autoantigen 1 (EEA1) bears an FYVE (Fab1p-YOPB-Vps27p-EEA1) domain which is an approximately 80 amino acid double-zinc binding motif that binds to PtdIns(3)P (phosphatidylinositol 3-phosphate). The FYVE domain is found in proteins involved in intracellular signaling, membrane trafficking, and cytoskeletal rearrangement. EEA1 binds to early endosomal membranes that contain PtdIns(3)P and plays a role in the docking and fusion of early endosomes. Alternative names for EEA1 include endosome-associated protein p162, Zinc finger FYVE domain-containing protein 2, and ZFYVE2.