Dopamine D1 R/DRD1 Antibody Summary
| Immunogen |
Synthetic 17 amino acid peptide from C-terminus of human DRD1.
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| Localization |
Cell membrane; multi pass membrane protein.
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| Specificity |
Human DRD1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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| Predicted Species |
Primate (94%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
DRD1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
ICC: Does not work.
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| Positive Control |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (100%), Gibbon (94%), Rat (88%), Elephant (88%), Porcine (88%), Sheep (82%), Hamster (82%), Panda (82%), Bovine (82%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Dopamine D1 R/DRD1 Antibody
- D(1A) dopamine receptor
- D1DR
- DADR
- Dopamine D1 R
- Dopamine D1 receptor
- Dopamine D1R
- dopamine receptor D1
- DRD1
- DRD1A
Background
DRD1, a Dopamine Receptor, mediates the effect of the neurotransmitter dopamine, an intermediate in the biosynthesis of noradrenaline and adrenaline. It is involved in the control of motor activity and cognitive memory. Downregulation of DRD1 leads to severe impairments in working memory and to locomotor hyperactivity, which are observed in diseases such as schizophrenia, Parkinsons disease, affective disorders, and attention deficit hyperactivity disorder. DRD1 enhances smooth muscle contraction and vasodilation in the heart. It also modulates sodium transport in the kidney and is involved in the pathogenesis of hypertension. Dopamine receptor D1 has been reported mostly in various regions of the brain. ESTs have been isolated from normal olfactory epithelium and cancerous genitourinary tract libraries.