DNA Ligase I Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 200 and 250 of human DNA ligase 1 using the numbering given in entry NP_000225.1 (GeneID 3978).
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| Predicted Species |
Primate (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
LIG1
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Northern white-cheeked gibbon.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for DNA Ligase I Antibody
- DNA ligase 1
- DNA ligase I
- EC 6.5.1.1
- ligase I, DNA, ATP-dependent
- MGC117397
- MGC130025
- Polydeoxyribonucleotide synthase [ATP] 1
- polydeoxyribonucleotide synthase ATP 1
Background
Eukaryotic DNA ligases are ATP-dependent enzymes that catalyse the joining of single and double-strand DNA breaks, which is an essential final step in DNA replication, recombination and repair. Four biochemically distinct DNA ligases, termed ligases I-IV, have been identified in mammalian cells. DNA ligase I is functionally homologous to the DNA ligase encoded by the Saccharomyces cerevisiae Cdc9 gene. The joining of Okazaki fragments during lagging strand DNA replication in mammalian cells is due to DNA ligase I.