Product: GS-7341 (hemifumarate)
DDR1 Antibody (2G4E12) Summary
| Immunogen |
Purified recombinant fragment of DDR1(aa602-681) expressed in E. Coli.
|
| Specificity |
Specific for DDR1.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
DDR1
|
| Purity |
Unpurified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
|
| Preservative |
0.03% Sodium Azide
|
| Purity |
Unpurified
|
Alternate Names for DDR1 Antibody (2G4E12)
- CAK
- CD167 antigen-like family member A
- CD167a antigen
- CD167a
- DDR
- DDR1
- discoidin domain receptor family, member 1
- discoidin domain receptor tyrosine kinase 1
- Discoidin receptor tyrosine kinase
- EC 2.7.10
- EC 2.7.10.1
- EDDR1
- ENTRK4
- Epithelial discoidin domain receptor 1
- HGK2
- MCK10
- MCK-10
- NTRK4
- Protein-tyrosine kinase 3A
- PTK3A protein tyrosine kinase 3A
- PTK3A
- receptor, type 4
- RTK6
- TRK E
- TrkE
Background
discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.