DCAF12 Antibody Summary
| Immunogen |
Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TCC52. The immunogen is located within amino acids 390 – 440 of TCC52.
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| Clonality |
Polyclonal
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| Host |
Chicken
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| Gene |
DCAF12
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for DCAF12 Antibody
- DDB1- and CUL4-associated factor 12
- CT102
- DDB1 and CUL4 associated factor 12
- KIAA1892
- TCC52
- WDR40A
Background
Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.