DAD1 Antibody

Product: Olmutinib

DAD1 Antibody Summary

Immunogen
Synthetic peptide from human DAD1.
Specificity
peptide corresponding to 14 amino acids near the C-terminus of human DAD1
Clonality
Polyclonal
Host
Rabbit
Gene
DAD1
Purity
Ion exchange chromatography
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Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Ion exchange chromatography

Alternate Names for DAD1 Antibody

  • DAD-1
  • defender against cell death 1EC 2.4.1.119
  • dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit DAD1
  • Oligosaccharyl transferase subunit DAD1
  • oligosaccharyltransferase 2 homolog
  • OST2

Background

Defender of cell death 1 (DAD1) was initially discovered in BHK21 cells as a negative regulator of programmed cell death, a process important for normal organism development and tissue homeostasis. DAD1 was later shown to be a subunit of the mammalian oligosaccharyltransferase complex and is required for its function and structural integrity. Mice lacking DAD1 express abnormal N-linked glycoproteins and undergo increased apoptotic-associated embryonic death. Furthermore, overexpression of DAD1 mRNA is seen in some human hepatocellular carcinomas, indicating it may also play a role in carcinogenesis. It should be noted that DAD1 is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.

PMID: 24050945