Ctip1 Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human B-cell CLL/Lymphoma 11A using the numbering given in Swiss-Prot entry Q9H165 (GeneID 53335).
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| Predicted Species |
Mouse (100%), Rat (100%), Porcine (100%), Primate (100%), Bovine (100%), Guinea Pig (100%), Monkey (100%), Rabbit (100%), Canine (100%), Equine (100%). Backed by our 100% Guarantee.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
BCL11A
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| Purity |
Immunogen affinity purified
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| Innovators Reward |
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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| Theoretical MW |
91 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Publications |
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear marmoset, Crab-eating macaque, Naked mole rat and Northern white-cheeked gibbon.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Ctip1 Antibody
- B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2
- B-cell CLL/lymphoma 11A (zinc finger protein)
- B-cell CLL/lymphoma 11A
- B-cell lymphoma/leukemia 11A
- BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1
- BCL-11A
- BCL11A-S
- BCL11A-XL
- C2H2-type zinc finger protein
- COUP-TF-interacting protein 1
- CTIP1ecotropic viral integration site 9
- ecotropic viral integration site 9 homolog
- Ecotropic viral integration site 9 protein homolog
- EVI-9
- EVI9FLJ34997
- HBFQTL5
- KIAA1809BCL11A-L
- Zinc finger protein 856
- ZNF856FLJ10173
Background
The B cell leukemia 11A protein (BCL11A/Evi9/CTIP1) has been implicated in hematopoietic cell development and malignancies. BCL11A is a transcriptional repressor that binds directly to a GC-rich motif and is also recruited to a promoter template via interaction with the orphan nuclear receptor, chicken ovalbumin upstream promoter transcription factor II. In both cases, BCL11A-mediated transcriptional repression is only minimally reversed by trichostatin A, suggesting the possible lack of involvement of class I or II histone deacetylases. Nonetheless, chromatin immunoprecipitation assays revealed that expression of BCL11A in mammalian cells resulted in deacetylation of histones H3 and/or H4 that were associated with the promoter region of a reporter gene. BCL11A mediated transcriptional repression, as well as deacetylation of histone H3/H4 in BCL11A-transfected cells, was partially reversed by nicotinamide, an inhibitor of class III histone deacetylases such as SIRT1. SIRT1 was found to interact directly with BCL11A and was recruited to the promoter template in a BCL11A-dependent manner leading to transcriptional repression. These findings indicate a role for SIRT1 in transcriptional repression mediated by BCL11A in mammalian cells.