Common beta Chain Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the N-terminus region of human IL3RB. The exact sequence is proprietary.
|
| Localization |
Membrane, Single-pass type I membrane protein
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
CSF2RB
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Theoretical MW |
97 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Common beta Chain Antibody
- beta, low-affinity
- CD131 antigen
- CD131
- CDw131
- colony stimulating factor 2 receptor, beta, low-affinity(granulocyte-macrophage)
- Common beta Chain
- CSF2RB
- cytokine receptor common subunit beta
- GM-CSF R beta
- GM-CSF/IL-3/IL-5 receptor common beta subunit
- GM-CSF/IL-3/IL-5 receptor common beta-chain
- IL-3 R beta
- IL3RB
- IL-5 R beta
- interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3receptor, beta (high affinity)
Background
Interleukin-3 receptor (IL-3R) is a heterodimer cytokine composed of alpha chain and beta chain. IL-3R beta subunit (CD131, beta C) is a common shared beta chain of the receptor for granulocyte- macrophage colony-stimulating factor (GM-CSF) and IL-5 (1). While the beta chain can not bind to the ligand alone, but it is essential for high affinity ligand binding (2). The cytoplasmic portion of the beta chain contains the major domains necessary for ligand-induced proliferation (3). IL-3R beta is expressed in neutrophil, eosinophil, monocyte, and hematpoietic stem cells. A point mutation leading to defective IL-3R beta expression has been associated to Human pulmonary alveolar proteinosis (PAP), a rare cause of respiratory failure (4).