Collagen XXV alpha 1 Antibody Summary
| Immunogen |
A synthetic peptide mapping to residues 430-443 [DYNGNLHEALQRIT] of the NC3 region of human and mouse CLAC-P.
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| Specificity |
This detects full-length CLAC-P and the secreted form of CLAC-P protein. It does not react with full-length or secreted forms of COLXIII protein or the COLXXIII protein.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
COL25A1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody has been tested in Western blot and immunohistochemistry-Paraffin. Suggested Starting Dilutions:* Western Blot: 0.2 ug/ml (ECL Overexpressed protein)
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Theoretical MW |
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Positive Control |
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Reactivity Notes
This antibody works in human and is expected to react with mouse protein.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Collagen XXV alpha 1 Antibody
- Alzheimer disease amyloid-associated protein
- AMY
- CLAC
- CLACP
- CLAC-P
- COL25A1
- Collagen 25
- collagen alpha-1(XXV) chain
- Collagen XXV alpha 1
- collagen, type XXV, alpha 1
- Collagen-25
- collagen-like Alzheimer amyloid plaque component
- collagenous Alzheimer amyloid plaque component
Background
Antibodies against senile plaque (SP) amyloid obtained a clone 9D2, which labeled amyloid fibrils in SPs and reacted with approximately 50/100 kDa polypeptides in Alzheimers disease (AD) brains. The 9D2 antigen was identified as CLAC (collagen-like Alzheimer amyloid plaque component), and its precursor as CLAC-P/collagen type XXV. Both secreted and membrane-tethered forms of CLAC-P/collagen type XXV specifically bound to fibrillized Abeta, implicating these proteins in beta-amyloidogenesis and neuronal degeneration in AD.