Collagen V Antibody [Biotin] Summary
| Immunogen |
Goats were hyperimmunized with human type V collagen.
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| Specificity |
Reacts with conformational determinants on human type V collagen as demonstrated by ELISA. May react with type V collagen from other species. Exhibits <10% cross reactivity with collagen type I, II, III, IV and VI. The antibody has not been tested for reactivity with other ECM proteins (e.g., laminin, fibronectin).
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| Clonality |
Polyclonal
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| Host |
Goat
|
| Gene |
COL5A1
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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| Readout System |
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS
|
| Preservative |
Sodium Azide
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Collagen V Antibody [Biotin]
- alpha 1 type V collagen
- Collagen 5
- collagen alpha-1(V) chain
- collagen, type V, alpha 1
- Collagen-5
- EC 2.7.7.6
- EC 6.1.1
Background
Collagens are highly conserved throughout evolution and are characterized by an uninterrupted “Glycine-X-Y” triplet repeat that is a necessary part of the triple helical structure. Type V Collagen is a member of group I Collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V Collagen binds to DNA, heparan sulfate, Thrombospondin, Heparin, and Insulin. Collagen V is composed of several subunits as follows: trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Type V Collagen is closely related to type XI Collagen and it is possible that the Collagen chains of types V and XI constitute a single collagen type with tissue specific chain combinations. Mutations in this gene are associated with Ehlers Danlos syndrome, types I and II.