Product: Angiotensin II 7-valine
Cofilin [p Tyr140, p Ser156] Antibody Summary
| Immunogen |
A synthetic peptide from the phospho Y140/S156 of human Cofilin-1 (Cofilin, non-muscle isoform) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse and monkey.
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| Modification |
p Tyr140, p Ser156
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| Localization |
subcellular location: nucleus matrix. cytoplasm, cytoskeleton. note: almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide. tissue specificity: widely distributed in various tissues.
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| Specificity |
Cofilin-1.
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| Clonality |
Polyclonal
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| Host |
Sheep
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| Gene |
CFL1
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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Reactivity Notes
Mouse, Rat and Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
No Preservative
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| Concentration |
LYOPH
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| Purity |
IgG purified
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| Reconstitution Instructions |
Reconstitute with 0.5 ml sterilized water. Add glycerol (1:1) for additional stability.
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Alternate Names for Cofilin [p Tyr140, p Ser156] Antibody
- 18 kDa phosphoprotein
- CFL
- cofilin 1 (non-muscle)
- Cofilin, non-muscle isoform
- cofilin-1
- p18
Background
Cofilin is a small phosphoinositide sensitive, actin binding protein capable of depolymerizing actin filaments in vitro. Under certain conditions, it fragments the filaments and accelerates actin subunit dissociation from their pointed (minus) ends. Cofilin binds stoichiometrically to monomeric G-actin and to actin protomers in filaments in an apparent pH-dependent, Ca2+ independent manner. Cofilin intercalates between longitudinally associated actin monomers within the filament and distorts its helical twist. Cofilin is ubiquitous in tissues of eukaryotes and is especially abundant in neuronal tissues. It is essential for viability and is important for many cellular processes involving actin remodeling such as motility at the leading edge of cells, polarized cell growth, endocytosis, phagocytosis, cellular activation, cytokinesis, and pathogen intracellular motility.