Product: Itraconazole metabolite Hydroxy Itraconazole
Chloroquine Inhibitor Summary
| Immunogen |
CAS Number 50-63-5
Empirical Formula (Hill Notation) C18H26ClN3. 2H3PO4 Molecular Weight 515.86 |
Applications/Dilutions
| Application Notes |
DNA intercalator. Also used to increase transfection efficiency.
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Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
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| Buffer |
Solubility:Deionized water
Form : White Solid (Powder) |
Background
Chloroquine is a weak base which can partition into acidic vesicles such as endosomes and lysosomes, resulting in inhibition of endosomal acidification and lysosomal enzyme activity. Because acidic pH of endosomes is a prerequisite of endosomal TLR activation, chloroquine can serve as an antagonist for endosomal TLRs. Chloroquine and its analog quinacrine are also known to act as therapeutic agents for autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, of which therapeutic activity is due to suppression of TLR9 activity as shown by researchers.