Calponin 1 Antibody (CNN1/832 CALP) [DyLight 650] Summary
| Immunogen |
Recombinant full-length human CNN1 protein (CNN1/832); Crude human uterus extract (CALP)
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| Localization |
Cytoplasmic
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| Marker |
Smooth Muscle Marker
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| Specificity |
Multiple isoelectric variants of calponin have been identified, however only two molecular weight isoforms exist; a 34kDa form and a 29kDa form. Expression of the 29kDa form, I-calponin, is primarily restricted to muscle of the urogenital tract, whereas the higher molecular weight variant has been demonstrated in vascular and visceral smooth muscle. In Western blotting, this MAb reacts with only the 34kDa form of calponin in extracts of human aortic medial smooth muscle and is unreactive with fibroblast extracts of cultivated human foreskin. Calponin is a calmodulin, F-actin and tropomyosin binding protein, which is thought to be involved in the regulation of smooth muscle contraction. Calponin expression is restricted to smooth muscle cells and has been shown to be a marker of the differentiated (contractile) phenotype of developing smooth muscle.
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| Isotype |
IgG
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
CNN1
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| Purity |
Protein A or G purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Optimal dilution of this antibody should be experimentally determined.
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Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
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| Buffer |
50mM Sodium Borate
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| Preservative |
0.05% Sodium Azide
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| Purity |
Protein A or G purified
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Alternate Names for Calponin 1 Antibody (CNN1/832 CALP) [DyLight 650]
- Basic calponin
- Calponin 1
- calponin 1, basic, smooth muscle
- Calponin H1
- Calponin H1, smooth muscle
- calponins, basic
- CNN1
- Sm-Calp
- SMCC
- SMCCcalponin-1