Calcineurin A Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 1 and 50 of human Protein Phosphatase 3, Catalytic Subunit, Alpha isoform using the numbering given in entry NP_000935.1 (GeneID 5530).
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
PPP3CA
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Human, Mouse
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Calcineurin A Antibody
- calcineurin A alpha
- Calcineurin A
- Calmodulin-dependent calcineurin A subunit alpha isoform
- CALN
- CALNA
- CALNAcatalytic subunit, alpha isoform
- CAM-PRP catalytic subunit
- CNA
- CNA1
- CNA1CALNA1
- EC 3.1.3.16
- PP2B
- PP3CA
- PPP2B
- PPP2BCCN1
- PPP3CA
- protein phosphatase 2B, catalytic subunit, alpha isoform
- protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform(calcineurin A alpha)
- protein phosphatase 3, catalytic subunit, alpha isozyme
- serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Background
Calcineurin, a major soluble calmodulin binding protein in the brain, a Ca2+/calmodulin dependent serine/threonine protein phosphatase, with a relatively narrow substrate specificity. This metalloenzyme, also known as phosphatase 2B, is a heterodimer composed of a calmodulin binding, catalytic alpha subunit 61 kDa, calcineurin A) and calcium binding beta subunit (18 kDa, calcineurin B). The Ca2+ binding subunit, calcineurin B, is immunologically conserved from yeast to mammals. The presence of 2 different calcineurin B isoforms (beta 1 and beta 2) has been reported in rat testis. The catalytic subunit of calcineurin, calcineurin A, isolated from different tissues or different organisms, exhibits some immunological heterogeneity. Further, there are at least 2 isoforms of calcineurin A in bovine brain (alpha 1 and alpha 2, 61 and 59 kDa, respectively).