Cadherin-16 Antibody (SPM594) [Biotin] Summary
| Immunogen |
Recombinant human CDH16 protein
|
| Localization |
Cell Surface with some cytoplasmic
|
| Specificity |
This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CDH16
|
| Purity |
Protein A or G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Optimal dilution of this antibody shomld be experimentally determined.
|
| Readout System |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
PBS
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A or G purified
|
Alternate Names for Cadherin-16 Antibody (SPM594) [Biotin]
- cadherin 16, KSP-cadherin
- cadherin-16
- Kidney-specific cadherin
- KSP-cadherin