CaMKIV Antibody

Product: Madecassoside

CaMKIV Antibody Summary

Immunogen
Synthetic Peptide: V(127) E K G Y Y S E R D A A D A V K Q(143) C
Localization
Cytoplasmic and Nuclear
Specificity
NB120-3557 detects CaM kinase IV (CaMKIV) from human, mouse, rat, canine, primate, arabidopsis and Xenopus Oocyte samples.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CAMK4
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.5 ug/ml
  • Immunohistochemistry 1:10 – 1:500
  • Immunohistochemistry-Frozen 1 ug/ml
Application Notes
WB: Detects an approx. 55 kDa protein representing CaMKIV in HeLa cell lysate.
Positive Control
HeLa Lysate (NB800-PC1)
CaMKIV Lysate (NBL1-08666)

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CaMKIV Antibody

  • brain Ca(2+)-calmodulin-dependent protein kinase type IV
  • brain Ca++-calmodulin-dependent protein kinase type IV
  • calcium/calmodulin-dependent protein kinase IV
  • calcium/calmodulin-dependent protein kinase type IV catalytic chain
  • calcium/calmodulin-dependent protein kinase type IV
  • CAM kinase- GR
  • CAM kinase IV
  • CaM kinase-GR
  • CaMK IV
  • caMK
  • CaMK-GR
  • EC 2.7.11
  • EC 2.7.11.17
  • IV
  • MGC36771

Background

CaM kinase IV (CaMKIV), in a calcium and calmodulin dependent manner, is implicated in phosphorylating numerous transcription factors including the CCAAT enhancer binding protein (C / EBP), serum response factor (SRF), and cyclic AMP response element binding protein (CBP). The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.

PMID: 17428998

CaMKIV Antibody

Product: R548

CaMKIV Antibody Summary

Immunogen
CAMK4 (NP_001735.1, 1 a.a. – 473 a.a.) full-length human protein. MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
Specificity
CAMK4 – calcium/calmodulin-dependent protein kinase IV,
Clonality
Polyclonal
Host
Mouse
Gene
CAMK4
Purity
Protein A purified
Innovators Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Learn about the Innovators Reward

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
Application Notes
Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control. It is also useful for IF.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

Quality control test: Antibody reactive against mammalian transfected lysate.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for CaMKIV Antibody

  • brain Ca(2+)-calmodulin-dependent protein kinase type IV
  • brain Ca++-calmodulin-dependent protein kinase type IV
  • calcium/calmodulin-dependent protein kinase IV
  • calcium/calmodulin-dependent protein kinase type IV catalytic chain
  • calcium/calmodulin-dependent protein kinase type IV
  • CAM kinase- GR
  • CAM kinase IV
  • CaM kinase-GR
  • CaMK IV
  • caMK
  • CaMK-GR
  • EC 2.7.11
  • EC 2.7.11.17
  • IV
  • MGC36771

Background

The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq]

PMID: 21091649