CXCR1/IL-8 RA Antibody Summary
| Immunogen |
Synthetic peptide (selective for CXCR1receptor from near C-terminal region).
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| Localization |
Cell Membrane
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| Specificity |
This antibody detects a single 55 kDa CXCR1 in PC-CXCR1 samples. The antibody does not cross reacts with other members of the CXCR family.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CXCR1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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| Publications |
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Reactivity Notes
Cross-reacts with Human and Rat. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Tris/Glycine buffer pH 7.5-7.9, stabilizing protein, and glycerol
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for CXCR1/IL-8 RA Antibody
- CD128
- CD181 antigen
- CD181
- CDw128aC-C
- chemokine (C-X-C motif) receptor 1
- CKR-1
- CMKAR1
- C-X-C chemokine receptor type 1
- CXCR1
- CXC-R1
- CXCR-1
- High affinity interleukin-8 receptor A
- IL-8 receptor type 1
- IL-8R A
- IL8R1
- IL8RA
- IL-8RA
- IL8RAC-C-CKR-1
- IL8RBA
- interleukin 8 receptor, alpha
- interleukin-8 receptor type 1
- interleukin-8 receptor type A
Background
Chemokine receptors belong to the superfamily of G protein coupled receptors, which regulate the trafficking and activation of leukocytes and operate as co-receptors in the entry of HIV1. CXCR1 is the receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. Binding of IL-8 to CXCR1 causes activation of neutrophils. CXCR1 expression also plays an important role in many inflammatory processes.