CSB Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 1161 and 1211 of human Cockayne syndrome protein B (excision repair cross-complementing rodent repair deficiency, complementation group 6) using the numbering given in entry NP_000115.1 (GeneID 2074).
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| Predicted Species |
Porcine (100%), Primate (100%), Monkey (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
ERCC6
|
| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
|
| Application Notes |
It is not recommended for Western Blot.
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Gorilla, Chimpanzee and Crab-eating macaque.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for CSB Antibody
- ARMD5
- ATP-dependent helicase ERCC6
- CKN2
- Cockayne syndrome group B protein
- Cockayne syndrome protein CSB
- COFS
- COFS1
- CSBCockayne syndrome B protein
- DNA excision repair protein ERCC-6
- EC 3.6.1
- EC 3.6.4.-
- excision repair cross-complementing rodent repair deficiency, complementationgroup 6
- Rad26 homolog
- RAD26
Background
ERCC6, also known as Cockayne syndrome B protein, is involved in DNA repair in response to UV exposure. ERCC6 has been reported to display ATPase and helicase activity and functions as a transcriptional regulator. Mutations in ERCC6 are the cause of Cockayne syndrome type B (CSB), cerebro-oculo-facio-skeletal syndrome type 1 (COFS1), De Sanctis-Cacchione syndrome (DCS), age-related macular degeneration type 5 (ARMD5), and UV-sensitive syndrome (UVS).