CREM Antibody Summary
| Immunogen |
Peptide with sequence LETLKDICSPKTDY corresponding to C-Terminus according to NP_853549.1, NP_874387.1, NP_874388.1, NP_874393.1, NP_874394.1, NP_877570.1, NP_877571.1, NP_877572.1, NP_877573.1, NP_878270.1, NP_898883.1.
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| Specificity |
This antibody is expected to recognise the following protein isoforms of human CREM protein: a (NP_853549.1); e (NP_874387.1); f (NP_874388.1); k (NP_874393.1); l (NP_874394.1); m (NP_877570.1); n (NP_877571.1); o (NP_877572.1); p (NP_877573.1); q (NP_878270.1); v (NP_898883.1). This antibody is not expected to cross-react with CREB protein.
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
CREM
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Approx. 35 kDa band observed in human heart lysates (calculated MW of 32.5 kDa band according to NP_853549.1).
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Rat, Bovine. Mouse reactivity reported in scientific literature (PMID: 22345550).
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for CREM Antibody
- cAMP response element modulator
- cAMP responsive element modulator
- cAMP-responsive element modulator
- hCREM 2alpha-b protein
- hCREM 2beta-a protein
- hCREM-2
- ICER
- inducible cAMP early repressor ICER
- Inducible cAMP early repressor
- MGC111110
- MGC17881
- MGC41893
Background
This antibody recognises a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.