CHMP4C Antibody

Product: Upadacitinib

CHMP4C Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human CHMP4C. The exact sequence is proprietary.
Localization
Cytoplasm; cytosol; Late endosome membrane
Predicted Species
Rat (91%), Bovine (91%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CHMP4C
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 10 – 1:500
  • Immunohistochemistry-Paraffin 1:100-1:1000
Application Notes
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
26 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
Preservative
0.01% Thimerosal
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CHMP4C Antibody

  • charged multivesicular body protein 4c
  • CHMP4c
  • chromatin modifying protein 4C
  • Chromatin-modifying protein 4c
  • hSnf7-3
  • hVps32-3
  • MGC22825
  • Shax3
  • SNF7 homolog associated with Alix 3
  • Snf7 homologue associated with Alix 3
  • SNF7-3
  • Vacuolar protein sorting-associated protein 32-3
  • vps32-3
  • VPS32C

Background

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM]

PMID: 23301527

CHMP4C Antibody

Product: Maytansinol

CHMP4C Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids:MSKLGKFFKGGGSSKSRAAPSPQEALVRLRETEEMLGKKQEYLENRIQREIALAKKHGTQN
Specificity
Specificity of antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CHMP4C
Purity
Immunogen affinity purified
Innovators Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Learn about the Innovators Reward

Applications/Dilutions

Dilutions
  • Western Blot 1:100 – 1:250
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:50 – 1:200
Application Notes
For IHC-Paraffin HIER pH6 retrieval is recommended.
Control Peptide
CHMP4C Protein (NBP1-81166PEP)

Reactivity Notes

Expected species cross reactivity based on sequence homology: Mouse (85%), Rat (84%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for CHMP4C Antibody

  • charged multivesicular body protein 4c
  • CHMP4c
  • chromatin modifying protein 4C
  • Chromatin-modifying protein 4c
  • hSnf7-3
  • hVps32-3
  • MGC22825
  • Shax3
  • SNF7 homolog associated with Alix 3
  • Snf7 homologue associated with Alix 3
  • SNF7-3
  • Vacuolar protein sorting-associated protein 32-3
  • vps32-3
  • VPS32C

PMID: 10604535