CHMP4C Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human CHMP4C. The exact sequence is proprietary.
|
| Localization |
Cytoplasm; cytosol; Late endosome membrane
|
| Predicted Species |
Rat (91%), Bovine (91%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
CHMP4C
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
26 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.0), 1.0% BSA and 20% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for CHMP4C Antibody
- charged multivesicular body protein 4c
- CHMP4c
- chromatin modifying protein 4C
- Chromatin-modifying protein 4c
- hSnf7-3
- hVps32-3
- MGC22825
- Shax3
- SNF7 homolog associated with Alix 3
- Snf7 homologue associated with Alix 3
- SNF7-3
- Vacuolar protein sorting-associated protein 32-3
- vps32-3
- VPS32C
Background
CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM]