Product: LY2365109 (hydrochloride)
CETP Antibody (ATM192) Summary
| Immunogen |
Synthetic peptide corresponding to residues C D(149) S G R V R T D A P D(159) of human CETP protein.
|
| Localization |
Secreted
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CETP
|
| Purity |
Protein A purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
||
| Application Notes |
WB: Detects adoublet at ~70 kDa from human serum representing CETP. May be useful in IP CETP activity from serum samples using protein G.
|
||
| Positive Control |
|
||
| Publications |
|
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
2 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for CETP Antibody (ATM192)
- cholesteryl ester transfer protein
- cholesteryl ester transfer protein, plasma
- HDLCQ10
- Lipid transfer protein I
Background
It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease.