CEACAM5/CD66e Antibody (CB30) Summary
| Immunogen |
Human carcinoembryonic antigen (CEA; CEACAM5)
|
| Specificity |
The antibody CB30 recognizes CD66e (CEA; 180-200 kDa), a cell surface bound carcinoembryonic antigen mainly expressed on epithelial cells.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
CEACAM5
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
For paraffin sections use standard ABC technique with pretreatment in 0.1% pepsin in 0.1M HCl for 30 minutes at RT
|
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
15mM Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for CEACAM5/CD66e Antibody (CB30)
- Carcinoembryonic antigen
- carcinoembryonic antigen-related cell adhesion molecule 5
- CD66e antigen
- CD66e
- CEA
- CEACAM5
- CEACAM-5
- CEACD66e
- DKFZp781M2392
- Meconium antigen 100
Background
The CD66e (CEA; 180-200 kDa) is a member of carcinoembryonic antigens, immunoglobulin supergene family and consists of a single N domain (structural homology to the immunoglobulin variable) and six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3). Human CD66e is heavily glycosylated GPI anchored protein capable of both homophilic and heterophilic adhesion. Disease relevance: The CD66e may play a role in the process of metastasis of cancer cells. CD66e is found in serum and it is clinically used as a tumor marker for early detection of disease due to its expression in adenocarcinomas potential target of tumor imaging and drug targeting.